A methodology towards assessing soil salinity hazard at irrigated areas of Colombia was developed based on both electrical conductivity and solubility of salts in water. First, irrigated areas were identified; and then, their physicochemical parameters were determined for characterizing electrical conductivity of water (ECw) as well as predicting salt contents in water by employing the Solsariego model. Afterwards, levels of salinity hazard were assessed by matching classes of ECw and solubility of salts in water. Finally, the salinity hazard was mapped for each irrigated zone. As a major conclusion, we consider that the methodological approach based on water quality assessment (ECw, salt contents, and their solubility in the irrigated water) allowed to prioritize hazard level. Hence, we can address activities for managing the soil salinity in the case study.