An experimental and computational study on the solubility of argon in propan-2-ol at high temperatures and pressures was performed. The following values of the Henry’s law constant for the solution of argon in propan-2-ol were obtained: 58 ± 3 MPa at 480 K, 99 ± 3 MPa at 420 K, and 114 ± 2 MPa at 360 K. Henry’s law constant for the solution of argon in propan-2-ol at high temperatures and pressures from experiment and molecular simulation is reported.