Cigarette smoking is considered the most important preventable public health problem in developed countries, especially among adolescents.To determine the prevalence of cigarette smoking and associated factors in high school adolescents, from a Colombian city.The self-administered global tobacco youth survey (GTYS) was answered by 831 teenagers aged 14 ± 2 years (54% females). For data analysis, proportions were calculated; for associations, binary and multivariable logistic regression was applied.Fourteen percent of respondents declared that they had consumed at least one cigarette during the last 30 days. The life-time prevalence of tobacco use was 27.1%. Being older than thirteen years old, father’s academic level and having a smoker mother were factors associated with smoking.The prevalence of smoking in these adolescents was high. Age over 13 years and a smoking mother were associated with the cigarette smoking.