Introduccion: la histerectomia es un procedimiento operatorio utilizado como tratamiento de patologias uterinas. Se ha senalado que su realizacion puede repercutir negativamente en algunas esferas e impactar la calidad de vida (CV). Objetivo: evaluar la funcion sexual, insomnio y CV en un grupo de mujeres histerectomizadas. Metodologia: estudio transversal realizado con tres escalas validadas: Indice de Funcion Sexual Femenina abreviado (IFFS-6), escala de insomnio de Atenas y Menopause Rating Scale (MRS), en mujeres con uno o mas anos de histerectomizadas, con edad entre 40- 59 anos, de etnias afrodescendientes y mestizas, residentes en el departamento de Bolivar, Colombia. Las participantes fueron captadas en sus propias comunidades. Resultados: fueron incluidas 202 mujeres, edad promedio 50.0±5.0 anos, 10.8% solteras, 85.1% unidas de forma estable, 3.8% separadas o viudas. El 69.8% eran mestizas. La media de la calificacion sexual fue 11.3±4.0 (rango 0 a 20, a mayor puntuacion mejor satisfaccion). El 29.7% tenia ooforectomia bilateral, el 28.7% unilateral y el 41.5% conservaban los ovarios. Solo el 20.3% utilizaba terapia de reemplazo hormonal. Disfuncion sexual se observo en el 71.7% de las mujeres, teniendo la mitad compromiso del orgasmo. El 71.2% manifesto presentar insomnio, con una puntuacion media de 8.1±4.5, teniendo la cuarta parte despertares durante la noche. El 42.5% presento deterioro severo de la calidad de vida, el 22.7% de la dimension somato vegetativa, el 37.6% de la psicologica y 52.9% de la urogenital. El 90.4% tenia sintomas vasomotores y el 25.7% informaron que tenian problemas sexuales severos o muy severos. La presencia de disfuncion sexual y de insomnio tuvo OR significativo para deterioro severo de la calidad de vida de 2.1 y 2.4, respectivamente. Conclusion: fue elevada la presencia de disfuncion sexual y de insomnio, ambas aumentaron dos veces el riesgo de deterioro severo de la calidad de vida. Cuatro de cada diez mujeres tuvieron deterioro severo de la calidad de vida, con mayor compromiso del area urogenital. Rev.cienc.biomed. 2014;5(2):235-246. PALABRAS CLAVE Histerectomia; Disfuncion sexual; Calidad de vida; Insomnio; Climaterio. SUMMARY Introduction: the hysterectomy is a surgical procedure used for the treatment of uterine pathologies. It has been demonstrated that this procedure could affect negatively different fields and to impact the quality of life (QoL). Objective: to assess the sexual function, insomnia and the QoL in a group of hysterectomized women. Methods: cross-sectional study carried out with three validated scales: The short 6-item Female Sexual Function Index (FSFI-6), the Athens Insomnia Scale (AIS) and the Menopause Rating Scale (MRS); in women with one or more years since the hysterectomy, aged between 40-59 years, belonging to afrodescendant and mestizo ethnic groups, who were from the department of Bolivar, Colombia. The participants were selected from their own communities. Results: 202 women were included in the study, with average age: 50±5.0 years. 10.8% were single, 85.1% were in free union and 3.8% were divorced or widowed. 69.8% were mestizo. The average score in the sexual grade between women with sexual partner was 11.3±4.0 (Range from 0 to 20, the higher the score, the better satisfaction). 29.7% had bilateral oophorectomy, 28.7% had unilateral oophorectomy and 41.5% kept the two ovaries. Just 20.3% used hormonal therapy. The sexual dysfunction was presented in the 71.7% of women, with disorder in orgasm in the 50.9%. 71.2% of women presented insomnia with an average score of 8.1±4.5. 28.6% expressed night awakenings. 42.5% of women manifested severe deterioration of the quality of life, 22.7%, 37.6% and 52.9% expressed deterioration of the somatic, psychological and urogenital domain, respectively. 90.4% of women had vasomotor symptoms and 25.7% reported to have severe or very severe sexual disorders. The presence of sexual dysfunction and insomnia had OR for severe deterioration of the quality of life of 2.1 and 2.4, respectively. Conclusions: the presence of sexual dysfunction and insomnia was high; both of them increased twice the risk of severe deterioration of the quality of life. Four of each ten women had severe deterioration of the quality of life with predominance in the urogenital area. Rev.cienc.biomed. 2014;5(2):235-246. KEYWORDS Hysterectomy; Sexual dysfunction; Quality of life; Insomnia; Climacteric