This success article refers to some basic imperatives for success in any event on entrepreneurship that has both the business world and own goals to achieve in everyday life. Pedagogical purpose is to show that the University is a favorable scenario to link to the different sectors of society to their construction of knowledge and scientific and technological production processes. It's a theoretical study based on the Protocol of a panel on entrepreneurship in the city of Monteria with four business leaders of the region. Technique is used as a method of work of the Protocol through the data record field book and then the classification and systematization of them seeking through theoretical assumptions reach the categorization of ideas. This work achieved six categories as imperatives of the University social responsibility in all prospective entrepreneurship. Similarly, the conclusions are proposed as imperatives motivators for success as a life project.