Introduccion : la intususcepcion intestinal en el adulto es una condicion poco frecuente, principalmente si se localiza en el colon, es un reto el diagnostico en el preoperatorio, tiene varias opciones de manejo que incluyen la via endoscopica, la quirurgica abierta y la laparoscopica. Caso clinico : paciente de sexo femenino de 51 anos, con cuadro clinico de dolor abdominal cronico, distension y perdida de peso. En el examen fisico se encontro desnutricion, abdomen sin signos de irritacion peritoneal y masa lisa, indolora en el tacto rectal. Hipoalbuminemia, anemia, parasitosis intestinal y antigeno carcinoembrionario normal. En el TAC se observaron signos de intususcepcion en el colon, por lo que fue llevada a cirugia. Se le practico desinvaginacion parcial del colon mas hemicolectomia izquierda mas colostomia de tipo Mickulickz. El estudio anatomopatologico reporto la presencia de un angiolipoma de colon de cuatro centimetros en la cabeza de la invaginacion. Evolucion postquirurgica satisfactoria. Debido a la rareza de la asociacion, se acompana la presentacion del caso de una revision tematica. Conclusion : el caso presentado tenia todas las caracteristicas clinicas descritas en la literatura. La intususcepcion del intestino grueso del adulto causado por una patologia benigna es un evento poco frecuente, pero debe estar presente en el diagnostico diferencial de la obstruccion intestinal del adulto. Rev.cienc.biomed.2012;3(1):155-161 PALABRAS CLAVES Intususcepcion de colon; Adultos; Lipoma de colon; Manejo quirurgico; Laparoscopia; Colonoscopia. SUMMARY Introduction: intestinal intussusception in adults is a rare condition, especially if located in the colon. Is a challenge in the preoperative diagnosis, management has several options including endoscopy, open and laparoscopic surgery. Case report: we report the case of a female patient of 51 years, with clinical symptoms of chronic abdominal pain, bloating and weight loss.On physical examination, it was found malnutrition, abdomen with no signs of peritoneal irritation and a painless smooth mass at rectal examination. Hypoalbuminemia, anemia, intestinal parasites and normal carcinoembryonicantigen, were also reported. The CT showed signs of intussusceptionin the colon, so she underwent surgery for partialreduction, left hemicolectomy and Mickulickz typecolon colostomy . The pathological study reported the presence of an angiolipoma of the colon measuring 4 cmon the intussusception head. The patient had a satisfactory postoperative evolution. Because of the rarity of the association, the presentation of the case was accompaniedof athematic review. Conclusion: this case had all the clinical features described in the literature. Intussusception in the adult intestine caused by a benign pathology is a rare event,but must be present in the differential diagnosis of intestinal obstruction in adults. Rev.cienc.biomed. 2012;3(1):155-161 KEYWORDS Intussusception; Adults; Colon lipoma; Surgical treatment; Laparoscopy; Colonoscopy.