The objective of this work is to compare the environmental impact of two different hot mix asphalt (HMA) materials used for road construction in Italy. The analyses used a “from cradle to gate” Life Cycle Assessment (LCA) boundary system and the methodology included considerations about raw materials and fuel supply, as well as transport and manufacturing processes. Primary data provided by the producers and secondary data available in the literature were used as part of the analyses. The results suggest that the proposed method offers rigorous criteria for a comprehensive assessment of the environmental impact of HMA materials, which could be used, among others, as an evaluation parameter in public bids.