Objectives: To describe some of thrombotic complications and thromboprophylaxis in patients with acute spinal cord injury (SCI), ASIA E classification admitted to the Clínica Universidad de la Sabana.Materials and methods: A retrospective observational case series of patients diagnosed with SCI ASIA E classification was conducted during the period 2014, 2015 and first 5 months of 2016, with follow-up at three months.Results: 13 patients with SCI ASIA E classification were detected. The average age of patients was 50 years [+/-18, 95]. The gender distribution was 4 women and 9 men (n = 13). With regard to the mechanism of trauma patients with spinal cord injury ASIA E, 2/13 (15.38%) was crushing and 11/13 (84.62%) falls. Patients who received enoxaparin thromboprophylaxis were formulated at doses of 40 mg SC daily. Pharmacologic thromboprophylaxis was performed in 10/13 (76.92%) cases of patients with SCI ASIA E classification. None of the patients had complications during hospitalization or follow-up at 3 months.Conclusion: Currently there is little scientific evidence to determine the factors of thrombotic risk and prevention of them in patients with SCI ASIA E, so that there is a lack of clarity and lack of guidelines based on evidence for this group of patients. This study is an approach for future studies on the need and effectiveness of nonapplication or pharmacological thromboprophylaxis in ASIA E classification.