Introduction: Amyloidosis is a disease of extracellular deposition of insoluble protein light chain forming amyloid fibrils sheet configuration with B pregueada pentraxin serum amyloid (APS). These substances can be deposited in any organ or tissue. When this occurs in the nasopharyngeal and laryngeal regions, it is an extremely rare event, especially if associated with systemic amyloidosis. Generally, the disease presents localized and not systemic, causing lumiais obstructions in the affected organs. The diagnosis is confirmed by pathological examination with Congo red staining.