Tedania brasiliensis is a rare species of marine sponge endemic to Brazil, which gave an anti-viral, antileishmanial and antitrypanosomal extract. Bioassay-guided isolation yielded a series of 16 new pseudoceratidine (1) derivatives with variable number of bromines and length of the triamine chain, as well as tedamides, unique alkaloids within this series bearing a completely modified pyrrole moiety. The potency against Leishmania infantum and Trypanosoma cruzi parasites of the isolated alkaloids showed influence by the bromination level, results which will be presented and discussed.