Traditional operation of distribution systems focuses on keeping user's voltage levels as close as possible to ranges around nominal values. However recent trends apply methods such as making more flexible the user's voltage level within regulatory limits to achieve optimization in distribution systems operation saving energy and obtaining other benefits including reducing CO2 levels. This paper explores the conceptual framework of the optimization of the distribution network's operation through the use of Smart Grids technology, providing significant benefits to the operation of electrical networks in Latin America. The Colombian case is illustrated to support the conclusion of the importance to introduce new operation methods to the electrical networks in the region.