Problem Women with antiphospholipid antibodies ( aPL s) present a risk of pregnancy morbidity ( PM ), vascular thrombosis ( VT ), or both ( PM / VT ). aPL s affect trophoblast function, and the aim of this study was to determine the modulation of this aPL ‐induced damage by different drugs. Method of study IgG was obtained from women with PM and PM / VT positive to aPL s. Binding of IgG to trophoblastic cells, proliferation, mitochondrial membrane integrity, and trophoblast invasion were assessed. The effect of enoxaparin, aspirin, and aspirin‐triggered lipoxin ( ATL ) were evaluated as well as signal transducer and activator of transcription 3 ( STAT 3) phosphorylation. Results IgG from women with aPL s strongly binds to trophoblastic cells. Integrity of mitochondrial membrane was reduced, and proliferation was increased by IgG‐ PM / VT . Both IgG‐ PM and IgG‐ PM / VT decreased trophoblast invasion, which was restored by enoxaparin, aspirin, and ATL . IgG‐ PM triggered reduction in STAT 3 phosphorylation. Conclusion Some drugs used to prevent aPL ‐induced PM modulated the alteration of trophoblast function.