The second worldwide cause for chronic kidney disease is diabetes mellitus which has individual and social economic repercussions. Glycosylated hemoglobin (HbA1c) is a metabolic control marker; its decrease is associated to a decrease of microvascular and neuropathic complications of diabetes. Objective: This study intends to determine the efficiency of an education program on Diabetes patients in peritoneal dialysis depending on Hb1Ac levels as a metabolic control parameter at a kidney dialysis unit in Cali, Colombia. Methodology: This is a quasi-experimental study conducted from June 2013 to February 2014. It included 150 type-2 diabetes subjects undergoing peritoneal dialysis assigned to 3 groups, according to an analysis using Pearson’s chi-squared test (χ2), Student t-test, anova, ancova and multiple linear regression, using IBM-SPSS®. Results: The sociodemographic clinical characteristics of the three groups did not present any significant baseline differences. A significant difference was observed in the post intervention knowledge of the group intervened using each module (p< 0.05). Hb1Ac levels had no statistically significant differences in 3 months. There was a difference after 6 months of the intervention in the intervened group in comparison with the two control groups (p< 0.05). Conclusions: Educational intervention can help to reduce Hb1Ac levels in a diabetic patient undergoing peritoneal dialysis if there is a continuous intervention.