Obesity is associated with adipose tissue inflammation that eventually results in insulin resistance (IR) and it is linked with type 2 diabetes mellitus [1]. Previous studies established the beneficial effects of fractions of Eucalyptus tereticornis (Eu) on carbohydrate metabolism in a diabetic mouse model. In addition, they showed a reduction in levels of proinflammatory cytokines in adipose tissue [2]. Our aim is to evaluate the effect of Eu fractions on inflammation and IR using murine adipocyte and macrophage cell lines.