Introduction: Leclercia adecarboxylata is an opportunistic gram-negative bacillus from the enterobacteria group, rarely isolated. It is generally reported as a single infection in immunosuppressed patients and less frequently in poly-microbial cultures in immune-competent patients. Clinical case: 60-years-old male with chronic kidney disease in haemodialysis since 2010, first by arteriovenous fistula and since 2014 by right jugular tunnelled catheter. During a session of haemodialysis, he presents an episode of chills and fever without apparent infectious focus; infection of catheter is suspected. Blood cultures are ordered, as well as beginning empirical therapy with vancomycin and amikacin via catheter. Blood cultures reported multisensible Leclercia adecarboxylata, presenting a good clinical response and negative blood cultures after treatment. Discussion: L. Adecarboxylata is an unusually isolated pathogen in sepsis by haemodialysis’s catheter and understudied in the literature. The importance of our case consists in being the first report in Colombia. The experience in other reports of this microorganism suggests that it has successful results with antibiotic treatment and no there’s no need to remove the catheter.