Purpose: We present the first physiological evaluation of the use of the light sword lens (LSL) for presbyopia compensation. The LSL is an axially asymmetric optical element designed for imaging with extended depth of focus. Methods: A monocular visual simulator setup is implemented to measure visual acuity (VA). Physiological presbyopia is “mimicked” in human subjects by paralysis of the ciliary muscle, using topical application of a muscarinic antagonist. The effect of a contact lens-configured LSL on the mimicked presbyopia visual system is evaluated by measuring VA as a function of target vergence. The ability of the LSL to compensate presbyopia for 2 photopic luminance values was also analyzed. Results: The average VA values for 11 subjects suggest that the LSL can compensate for presbyopia across a wide range of target vergences for which the LSL was designed (−3 to 0 D). However, the proposed corrector element causes a loss of distance VA. The mean logMAR VA in that target vergence range was 0.07. The VA curves also show that luminance does not affect the expected behavior of the LSL-corrected presbyopic eye. Conclusions: These results indicate that the LSL has significant potential as a visual aid for presbyopia.