The stage business and existing at this time development proposes to companies the challenge function and coexist in the environment of organizational systems partner, thanks to its impact on the business development, specifically for the micro, small and medium-sized enterprises, and their contribution to the growth of the region. This situation has aroused concern in scholars and researchers to analyze this business from its impact on the execution of the signatures. From the above reasoning, this paper analyzes the impact generated by the link between the companies and the establishment in relation to processes of entrepreneurial creativity in the municipalities of the Department of Cundinamarca (Colombia). The paper for this research is empirical and the results are part of the construction of the theoretical framework that gives support to research that generates it. The product resulting from this work shows that ties linking business organizations analyzed in order to carry out research and development and transfer of knowledge, within the framework of associations of entrepreneurs, contribute helpful fashion to the improvement and growth of organizations.