This commentary discusses Anas Wayúu, an Indigenous health organization (non-profit health care insurance company) in Colombia. It analyses the crisis of the Colombian health care system, the creation of Indigenous health organizations, and the success of Anas Wayúu. The commentary was written using document reviews and secondary sources. We conclude that Anas Wayúu shows the strength and skill of Indigenous organizations to manage their health care, and the enormous potential for improved health status.