<b>Background:</b> It has been reported that the presence of involuntary stops during the six minute walk test (6MWD) is associated with increased mortality in patients with COPD. However, the relationships of these stops with other variables calculated from the 6MWD such as speed, work, the product distance-saturation (DSP), the desaturation distance ratio (DDR) and exercise-induced desaturation, have not yet been established. <b>Materials and Methods:</b> An observational, retrospective study in 129 subjects with COPD that completed a 6MWD. The derived variables from the 6MWD were compared between patients with and without involuntary stops, correlations were identified and predictors of stops were determined through logistic regression analysis. <b>Results:</b> Thirty patients presented involuntary stops during the test; scores of dyspnea and fatigue, as well as the heart rate (HR), respiratory rate (RR) and final systolic blood presure (SBP) were significantly higher than in the group that did not stop, while SaO2 was significantly lower (p< 0.001); of the new derived variables, distance, speed, work, DDR and DSP were lower (p< 0.001) in those who stopped, with a good correlation. In the regression analysis, the variables that remained significant for the presence of stops were saturation at the end of the test, distance, speed, work, DDR and DSP. <b>Conclusions:</b> In patients with stable COPD who perform a 6MWT, the presence of stops is associated with less distance, work, DSP, DDR and saturation at the end of the test. The calculation of these new variables and the recording of involuntary stops during the 6MWD could refine the prognostic ability of the test in COPD.
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Chronic Obstructive Pulmonary Disease (COPD) Research
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FuenteAmerican Journal of Respiratory and Critical Care Medicine