Primary herpetic gingivostomatitis is a viral contagious disease which is caused by the herpes simplex virus type 1 HSV-1.It is principally observed in little children, being probably the first exposure of the child with the virus.This condition is very common however it is still very painful and to be taken care of.The treatment generally consists of a management of the virus at a systemic level, complementing with other palliative measures to decrease the symptoms and the possibility of a secondary infection.The objective of this article is to present two cases of primary herpetic gingivostomatitis in the gums, hard palate, lip semimucosa and tongue.The treatment used consisted of systemic management with acyclovir and acetaminophen, complementing with oral rehydration salts, liquid diet and hospital observation, obtaining very favorable results in a short amount of time.