<p><strong>ABSTRACT. </strong><em><strong>Background:</strong></em> Dental materials, including dental amalgam, undergo macro-structural changes when exposed to high temperatures. Understanding those changes can be useful for dental identification and documentation when conducting medical-legal autopsies of burned, charred, or incinerated bodies to determine type of biomaterial and highest temperature reached. <em><strong>Purpose:</strong></em> Describe the formation of silver nodules on the surface of dental amalgams exposed to high temperatures, in order to identify patterns and reliable markers for forensic dentistry use. <em><strong>Methods:</strong></em> This was a quasi-experimental <em>in vitro</em> study that described the formation of silver nodules in a sample of 45 dental amalgam discs (brands: Contour® Kerr®, Admix® SDI®, and Nu Alloy® New Stetic®) and 45 occlusal fillings in premolars that were exposed to high temperatures (200º C, 400º C, 600º C, and 800º C). <em><strong>Results:</strong></em><strong><em> </em></strong> Silver nodules were evident on the amalgam surfaces between 200º C and 400º C and began to disappear at 600º C to form spheres and strips upon reaching 800º C. <em><strong>Conclusions:</strong></em> The formation and disappearance of silver nodules is a recurring feature of new-generation amalgam alloys exposed to extreme temperatures. Therefore, describing them can be used as a marker to identify materials and determine highest temperature reached by human remains.</p><p> </p>