In this paper a methodology that combines a classical PID control strategy and new simulation scenarios is proposed for controlling intersections in the city of Medellín. There are several advantages of PID controllers. The simple computation of the PID control is a remarkable advantage in real time applications, which motivates its application in this work. In addition, and with the objective to simulate a real intersection, a methodology for setting up urban traffic simulation scenarios involving tools such as SUMO and Traci4Matlab is used in this paper. Finally, with the purpose to illustrate the performance of PID controllers at road intersections, the methodology proposed here is applied in a well known intersection in the city of Medellín.