Carriers of autosomal-dominant Alzheimer’s disease (ADAD) mutations provide a unique model for studying the earliest physiological changes associated with Alzheimer’s disease (AD). In AD, deficits in episodic memory have been linked to failure of a large network of brain areas, including medial temporal lobe and parietal regions. This study used functional MRI (fMRI) to examine recognition memory function in a group of healthy, young, cognitively-unimpaired individuals, who carry the E280A presenilin-1 (PSEN1) genetic mutation, which causes ADAD with almost complete penetrance. These individuals will go on to develop the first symptoms of the disease around the age of 45 years. Subjects were 8 PSEN1 mutation carriers (6 female, mean age 35.2, SD=4.9) and 8 non-carrier family members (6 female, mean age = 36.4, SD = 6.5) from a Colombian kindred. All participants learned a set of 86 face-name pairs, and then performed a forced-choice recognition memory test while in a 1.5T fMRI scanner. During recognition, faces were presented with two names underneath—one name that had been paired with the face in the learning phase, and the other a distracter—and were asked to identify the correct one. fMRI task-related analyses were restricted to the contrast of correct vs. incorrect responses. Behaviorally, there were no significant differences in accuracy or reaction time between the groups (p<0.05). Both carriers and non-carriers showed activation in fronto-parietal regions during recognition of face-name pairs. Asymptomatic carriers exhibited less activation in bilateral parietal regions (e.g. precuneus, p=0.002 uncorrected) during recognition, compared to age-matched controls. Our preliminary results demonstrate that functional changes within the memory system occur years before clinical onset in ADAD. These preclinical changes suggest that fMRI patterns during episodic memory retrieval may be useful for early detection of Alzheimer’s disease. Further analysis and a larger sample size are needed to follow up on this preliminary result.