The potential clinical value of the widening of pulse pressure (PP) as a Alzheimer disease (AD) risk factor. The study included a total of 119 participants. The study logistics complied with the Declaration of Helsinki. PP as defined as the difference between the systolic and diastolic pressure readings and the risk of Mild Cognitive Impairment (MCI) to Alzheimer's Disease was evaluate with The Montreal Cognitive Assessment (MoCA) is a test for detection of MCI. Bivariate analyses with Non parametric measures (Spearman).The SPSS for Windows (version 16.0) was used for statistical analyses. All p values < 0.05 were regarded as statistically significant. The general characteristics of the study was 119 participants, 74 women and 45 men; mean age of 72.8 ± 8.2 years, 82 participants with MCI risk . We conducted bivariate analyses PP was not significantly associated with MCI risk (ρ: -0,89 p<0.016). PP is an important risk factor for cardiovascular disease and as a measure of early vascular aging but it is unknown the relationship with risk of Mild Cognitive Impairment to Alzheimer's Disease. This study shows a negative relationship between pulse and MCI.