Salvia is the most diverse genus in the Lamiaceae family, with close to 1000 species distributed around the world. In the Americas the genus is represented by approximately 600 species. Several species of Salvia are cultivated for their aromatic characteristics and are used as flavorings, food condiments, cosmetics, perfume additives and as folk medicines. As a part of our continuing search for novel, plant-derived biological agents, Salvia bogotensis was studied. Several separations using column chromatography (silica gel, Sephadex LH-20) and preparative TLC were performed to afford two new coumarin derivatives 1 – 2, a new glucoside monoterpenoid 3 and eleven previously known compounds. The structures of compounds were determined on the basis of HRMS, and 1D and 2D NMR studies, as well as by comparison with data from the literature. The new compounds do not show affinity to opioid and cannabinoid receptors, and showed moderate activity in antibacterial, antifungal, antimalarial and antileishmania assays.