The aim of this chapter is to define the requirements for the design of a Decision Support System (DSS), in order to address the problems associated with loading and unloading of goods operations in Bogotá, Colombia. The requirements definition is based on information obtained from the project “Formulación de alternativas para el cargue y descargue de mercancías en Bogotá” developed by the Universidad Nacional de Colombia. We present a literature review concerning with the relevance of developments and application of this kind of systems in cities such as Bogotá, regarded by some authors as a megacity in Latin America. The definition of the design requirements of the system is rooted in the identified needs of the stakeholders involved in urban logistics operations with the aim of encompassing and providing reliable information that favors the design of a DSS adapted to identified conditions.