In this paper was done the compilation of Particulate Matter (PM) concentrations for the largest cities in Latin America, with over 1 million inhabitants in order to investigate the air quality situation in this region. For this study were obtained data from 28 cities of 13 countries from the World Health Organization reports (WHO), government agencies and monitoring stations. The results shows that, in most cities, the levels established by WHO guidelines, both PM10 and PM2.5, are exceeded, providing conditions that threaten the public health of citizens.