Cerebral tuberculoma is a rare cause of intracranial mass.In Latin America and Colombia where tuberculosis is endemic, it represents between  and  of brain tumours.A -year-old Colombian woman was admitted to a third-level hospital in Cali, Colombia, after reporting loss of consciousness, headache, paresthesia, and fl ight of ideas for a two-week period.Imaging studies showed a left frontal mass of malignant appearance whose fi rst possible diagnosis was metastatic neoplasia or glioma.With the initial results, absence of history of chronic infectious diseases and a history of thyroidectomy, a surgical procedure was carried out and a histopathological and molecular evaluation was conducted.Th e pathology report noted necrotizing granulomatous infl ammation and tissue staining and molecular tests for detection of M. tuberculosis were positive and the patient was managed with anti-tubercular treatment.Intracranial masses are frequently targeted as a malignant neoplastic disease for surgical treatment.Considering an infectious etiology must be a diagnostic option.