Objective. To evaluate microbiological quality of human-consumption water, taking into account potability microbiological indexes, at intake sites, through determination of contamination indicator microorganisms, such as total coliforms, Escherichia coli y Aerobic mesofilos , Salmonella spp. Methods . 554 samples of water were collected, in independents sampling in seven municipalities of the Caribbean region, during the term 2005 through 2008. Results and Discussion. From the 554 analyzed samples it was found that 98.3% of the water samples, is not apt for human consumption, and domestic activities. The origin of faecal contamination seems to be more related to the distribution network than treatment plants. Conclusion. It is important to oversee water microbiological quality from the natural source, and implement proper collection systems, distribution, and storing a home, which ensure water innocuousness through its final destination, taking into account that when contaminated it turns into a strong risk against economic activities of the area, and the population is at risk of getting hydric-origin diseases, resulting in a health unbalance.