Medicinal knowledge in the indigenous reservation of Macedonia is based on the management of medicinal plants such as "home remedies". Yarumo (Cecropia sciadophylla), Carambolo (Averrhoa carambola) and Cat's Claw (Uncaria tomentosa) can be stand out because their cultural use value. Using semi-structured interviews on the community, it was analyzed aspects related to the impact of migration processes in the acquisition of knowledge, transmission of medicinal plants knowledge, ignorance of its medicinal use, report uses of medicinal plants and practices in the remedies preparation. The medicinal plants knowledge is highly permeate by migrational process on the Amazon territory and transnationalism. This was mostly concentrated in the grandparents knowing who had more contact and have experienced with the plants. This study reported 17 uses from Cat's Claw, followed by 11 uses of Carambolo and 10 uses of Yarumo.