Medicinal and aromatic plants and other natural products are important sources of valuable substances. These substances are often labile and therefore mild methods should be applied to isolate them from the plants. Supercritical uid extraction (SFE) is particularly suited for such isolation as it does not expose the substances to high temperatures and is relatively fast due to outstanding transport properties of supercritical uids. The most frequent supercritical solvent is carbon dioxide, which is as a "green" solvent much more acceptable than toxic conventional organic solvents.