Research in developing artificial tissue has emerged during the two last decades around the world.In the same manner that surgical grafting of natural tissue, artificial tissue grafting aims to promote the replacement of lost tissue by one that has similar morphology and function.Artificial tissue does not completely prevent fibrotic scarring and wound contracture.However, in many cases its use has proved to result in better healing.Currently, in the Latin America region the advantages and disadvantages of skin and oral wound therapies based on grafting artificial tissue are only known by a reduced group of scientists working in the field and by the few clinicians willing to use them.For that reason, it is important to inform on skin and oral mucosa tissue engineered products and the advantages and disadvantages of applying them.This chapter surveys the origin of artificial tissue manufacturing, some biological bases of tissue engineering, skin and oral mucosa tissue substitutes approved for human use, and their clinical application.