Documents governance issues in the design and implementation of some successful or promising population-wide interventions intended to prevent health risk factors in Latin America and the Caribbean (LAC), including Argentina's policies to reduce the consumption of trans fats and sodium; Bogotá's (Colombia) built environment promoting physical activity; Mexico's National Agreements on Food Health (Strategy against Overweight and Obesity); and Uruguay's anti-tobacco policies. Specifically, these case studies examine (1) which stakeholders participated directly or indirectly in the decision-making process; (2) what positions they held; (3) which incentives they faced; (4) which strategies they pursued; (5) how existing institutional arrangements affected the decision-making process; (6) what lessons can be drawn from these processes; and (7) what the successes and setbacks were. Each case study, selected from major population-wide, multisectoral programs in the region, examined a program or policy targeting a distinct risk factor in a different country to ensure a wide representation.