In the current peak of development and implementation of mobile applications in educational settings, it is becoming an urgent matter to propose pedagogical approaches that addresses the complex educational dynamics for mobile teaching and learning. Previous studies have suggested different models to implement mobile technologies in educational settings. However, few of them recognize the specific reality of an educational setting and the difficulties that must be assumed by teachers in mobile teaching design and implementation. Consequently, this book chapter examines theoretical and empirical work of previous proposals in order to develop a framework of M-learning aimed to teachers who want to innovate their learning environments using mobile devices. To this end, it was conducted a theoretical and empirical validation of the proposed model in order to design a framework that addresses practical aspects of the context of teachers considering pedagogical use of mobile technology. Finally, the results and conclusions of this proposed model are expected to contribute in the construction of an educational model for mobile technology integration.