Computer simulation is an important tool for the study and analysis of communication networks. In the case of simulation of Vertical Handoff Algorithms (VHAs) for heterogeneous wireless networks there are two approaches: using a network simulator or using general purpose programming languages. The objective of this chapter is to present and compare both approaches, by means of two study cases. The first case considers the use of network simulator NCTUns (National Chiao Tung University Network Simulator), while the second case considers the use of MATLAB.