The objective of this chapter is to review and discuss sustainability and techno-economic criteria to integrate pyrolysis, biochar activation, and bio-oil refining into sustainable business models. Several business models such as the production of biochar with heat recovery and bio-oil refining are discussed. Cost data needed by engineering practitioners to conduct enterprise-level financial analyses of different biomass pyrolysis economy models are presented. This chapter also reviews life cycle assessments of pyrolysis business models. If the feedstock used is produced sustainably and if the pyrolysis vapors are used for bio-oil or heat production, both, the production of biochar through slow pyrolysis and its use as a soil amendment to sequester carbon, and the production and refining of fast pyrolysis oils to produce transportation fuels could have a positive environmental impact.