Rheumatoid arthritis (RA) is a systemic autoimmune polyarticular synovitis involving large and small joints resulting in pain, joint destruction and disability. The disease course of RA is unpredictable with some patients having only mild symptoms while others may experience persistent and acute synovitis leading to severe joint destruction. The pharmacological treatment of the disease includes nonsteroidal anti-inflammatory drugs, glucocorticoids (GCs), conventional disease-modifying antirheumatic drugs (DMARDs) and finally, biologics.