Abstract In response to an increasing burden of breast cancer in LMICs, programs are being advocated, initiated, or expanded to provide early detection, diagnostic, and treatment services. Early detection efforts should only be initiated if adequate diagnostic and treatment facilities are available. In countries in which women with breast cancer typically present with advanced tumors, programs to promote earlier treatment of symptomatic disease may be the most appropriate initial activities. Evidence-based guidelines for the provision of screening, diagnostic, and treatment services commensurate with varying levels of available resources have been developed, and their use should be promulgated. All programs for the early detection of breast cancer should be conducted in such a manner that they can be evaluated to determine whether down-staging of disease at diagnosis has been achieved and to assess the level of coverage in the population.