Clinical report of a 27-year-old patient diagnosed with trisomy 16 and congenital cervical scoliosis; within the oral clinical manifestations of the disease were found agenesis of upper lateral incisors, ankyloglossia, over-inserted labial frenulum and high and arched palate; also the patient showed generalized marginal gingivitis associated to plaque with a loss of attachment level in dental organs 31 and 41. Partial or complete trisomy 16 are considered non-compatible with life; this anomaly corresponds to 2% of the causes of abortion in the first trimester; SH and DP Roberts Duckett reported a case of survival of 10 months, and in this case, the survival is 27 years.