Various studies place university teaching as a one the professions at higher risk to experience instability and occupational stress. The present research explored the level of burnout and emotional intelligence skills in a sample of 60 full-time professors at the Pontificia Universidad Catolica del Ecuador, sede Ambato. Analysis of multiple mediation were conducted and found that: a) the research and the social work are significantly associated with burnout, and the task of teaching is perceived with optimal performance, b) health mediates the relation between occupational stress and burnout, and gender is only related to burnout, and c) emotional regulation mediates the relation between professoCs performance and occupational satisfaction. The implications of these findings in the occupational health of university professors are discussed.