The Colombian healthcare industry has been growing since the late 90’s and the amount of spending allocated to this sector is the highest proportion of GDP in Latin American countries. Those facts have increased the importance of this sector for the economy and national development. Furthermore, enterprises with IT governance that focus on organizational objectives have yielded superior results than their competitors (Weill & Ross, 2004). The authors performed a research project to find out if there are similarities amongst Colombian Health Sector Enterprises that have obtained positive results. In this project, the authors studied IT governance, operational model, engagement model, and portfolio management of twelve companies, all of them large to medium-sized. The results show that the IT governance behavior of the Colombian healthcare industry is not homogeneous. Different subsectors have different behavior; some perform as large superior global enterprises and others are beginning their journey.