In this work the phase equilibrium data for the mixture isoamyl acetate (iAAc) + isoamyl alcohol (iAA) at pressures of 50.00, 101.32, 250.00, and 350.00 kPa in a dynamic recirculation cell (Fischer Labodest VLE model 602) were measured. The existence of a minimum boiling point azeotrope and the effect of the pressure on the azeotropic composition were determined. The data obtained experimentally were evaluated by means of a thermodynamic consistency analysis to validate the data quality and to use it in data regression to obtain the adjusted aij parameters for the nonrandom two-liquid (NRTL) model at each system pressure. Finally, a pressure swing distillation separation scheme is proposed. The main operating conditions of this separation alternative are defined by simulations in the Aspen Plus software platform in order to obtain high-purity components.