Abstract Traditionally used by various ethnic groups and peasants in the region of Putumayo-Caqueta, Colombia, yage remained confined for decades to rural and urban folk sectors. However, since the early nineties, ritual consumption of yage has had a profuse dissemination among middle and elite social sectors in cities across the country. Increasingly, intellectuals and artists are inviting taitas (indigenous shamans) to perform yage ceremonies in the city. Offered as “traditional indigenous medicine,” yage consumption has been institutionalized around new taitas who combine practices of indigenous traditions with new ritual forms. More recently, urbanization of yage has led to the formation of clusters of neoyageceros around these new taitas. Best known as malocas, these groups have institutionalized ritual consumption of yage, offering numerous kinds of therapeutic and spiritual services. This chapter analyzes and contrasts two new taitas and their malocas in the city of Pasto, in southern Colombia.