In the last decade, e-commerce has achieved rapid evolution from simple and static systems on the Web that provided information and promoted products to complex systems and dynamic applications that support business processes. Reuse and interoperability are strategies to face the challenge in software development in a dynamic context and rapid technological changes. To achieve these strategies, it is necessary to work with conceptual models that faithfully collect business semantics and, through of automatic tools (or semiautomatic) model transformation, get the model to be implemented in the appropriate platform. In this chapter, to successfully perform such a task, the authors work on a methodological framework with model-driven technologies that are considered the most appropriate approach, both technically and economically, so that organizations can easily adapt to the technological changes that arise at any time.