Objective: We offer an approach of scientific literature based on the best available evidence of the different medical treatment options for uterine fibroids.Method: A search of the literature in the databases in Med Line PubMed, Embase, Cochrane, Ovid-Hinari, Scielo, and Lilacs.Results: 212 articles were reviewed and 58 articles were selected, which were directly related to the topic.GnRH agonists are the only drugs approved by the Food and Drug Administration for reducing the volume of fibroids, used pre-surgically, but have many side effects.The levonorgestrel-releasing device is proposed as an option for patients with fibroids under 6 centimeters and without involvement the uterine cavity.Selective progestin receptor modulators and aromatase inhibitors arise as a management that can be useful, especially for patients in peri-menopause.Conclusions: The literature shows that there is evidence of several drugs that can be used for the management of patients with fibroids especially for the management of associated symptoms to improve quality of life and benefit more patients are those closest to the menopause.Finally there are other drugs that are under investigation and may be future therapeutic options for use both together as myomectomy and exclusive use of medical treatment.