There is increasing evidence that subjective memory complaints (SMC) may be one of the earliest clinical signs of preclinical Alzheimer's disease (AD) in late-onset AD. Understanding the relevance of SMC in early-onset AD is relatively underexplored. Our goal was to examine self-reported and informant-based SMC in young cognitively-intact individuals who carry the E280A mutation in presenilin-1 (PSEN1) gene and age-matched noncarriers. Furthermore, we sought to examine the association between SMC with hippocampal volume. Participants were 51 cognitively-intact volunteers from a Colombian kindred with autosomal dominant early-onset AD; 25 were positive for the AD-associated PSEN1 mutation (mean age 34 +/- 7 years), whereas 26 were noncarriers (mean age 37 +/- 6 years). All participants underwent comprehensive clinical and neuropsychological assessments, and structural MRI scans. Participant-informant dyads were asked to complete a 15-item questionnaire of SMC (Acosta-Baena, et al. 2011). We compared groups using t-test analyses and calculated Cohen effect size (d). Pearson correlation coefficients (R) were performed to explore the associations between ratings of SMC and hippocampal volume. Groups did not differ in age, education, ratio of men to women, or performance on cognitive measures (e.g. memory, language, visuospatial and executive functioning). There were no differences between groups in hippocampal volume. Self-reported ratings of SMC were higher in the carrier group compared to the non-carrier group (d= 0.72, p-value= 0.01), whereas there were no differences across groups for the informant-based ratings. In the carriers alone, informant-based ratings of SMC were significantly correlated with hippocampal volume (R= -0.47, p-value=0.04). These findings suggest that self-reported ratings of SMC may be the earliest sign of subtle cognitive changes in preclinical familial Alzheimer's disease. By contrast, informant-based ratings may be more relevant for diagnosis as the AD-related limbic neurodegeneration progresses. Further research is needed to determine whether ratings of SMC could be useful for identifying individuals at high risk to develop AD.