The list of Crustacean species from the state of Santa Catarina, southern Brazil, comprises 518 valid species, distributed in 17 orders and 152 families. This amount corresponds to 0.75% of the Crustacea worldwide and about 20% of Brazilian species. The order Decapoda is the most represented, with 280 species. The families of Decapoda with the greatest number of species recorded were: Aeglidae (19), Palaemonidae (13) and Portunidae (13). In addition, the occurrence of 19 species distributed in the orders Cyclopoida (1), Podocopida (2) and Decapoda (16) is reported for the first time. Exotic species (9) are distributed in four different orders - Isopoda (6), Calanoida (1), Thoracica (1) and Decapoda (1).