Objective: To establish contamination by Vibrio in oysters ( Crassostrea rhizophorae ) caught in De La Virgen Swamp, in order to alert entities in charge or protecting consumer health in Cartagena city. Methods: Between February and April 2006, 67 oysters from 5 strategic sites along De La Virgen Swamp, were analyzed. Insulation and identification of Vibrio was performed through a culture and biochemical tests. Results. Predominant species were V. alginolyticus (23%), V fluvialis (20%), V. parahaemolyticus (10%), V. carchariae and V. mimicus (13%), V. vulnificus, cincimatiensis y V. campbelli (7%). The sampling point with a higher number of isolation was Mangles Cielo Mar sector (30%). There were no statistical difference among sites. Conclusions. Vibrio Cholerae absence in this study, could be associated to the lack of halophilous serotypes, therefore their growth would be inhibited by high salinity at the capturing places.