Implementation of the e-learning model in Latin America is at a growing stage, meeting the quality parameters in relation to transversal and specific competences development.This article shows the results of an analysis of the development of transversal competences (cognitive, socio affective, and communication competences) and skills in managing hardware and software for the implementation of e-learning in a professional undergraduate program.The methodology used for this study was a mixed one; qualitative research to describe attitudes, behaviors and motivations of the students in the use of the e-learning model, and quantitative research to measure the level of expertise in the use of the model by students.The results reveal that success in the development of the described competences in the use of the e-learning model depends on the level of expertise they students and teachers acquire, as wel as on the initiative of teachers in instructional design and monitoring of the performance of their students.