A 43-year-old women is suffering from immobilizing generalized muscular pain. Initial diagnostic course doesn't lead to diagnosis. Some days later after appearing of a facial palsy a Guillain-Barré syndrome is diagnosed after lumbar puncture showing a increased protein and normal white-cell count. Because the patient is seriously affected with immobilization a treatment with intravenous immunoglobulin is established, leading to a quick improvement. Pain as a leading symptom of Guillain- Barré syndrome and has a potential for leading to misdiagnosis effecting delay in therapy in possible harmful disease.